Influence of antidiabetic drugs on the activity of nonsteroidal anti-inflammatory drugs in carrageenan paw edema test in the rat.

Interactions between anti-inflammatory drugs and anti-diabetic drugs particularly sulphonylureas are known. Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone and oxyphenbutazone are known to potentiate (I, 4, 5) and indomethacin and ibuprofen are known to antagonise the hypoglycaemic effect of oral sulphonylurea drugs (2). On the other hand Wellinger et al. (12) reported that insulin and tolbutamide potentiate antiinflammatory effect of indomethacin. As various NSAIDs interact differently with oral antidiabetic drugs and insulin is reported to alter the prostaglandin synthesis (6), it was worthwhile to investigate the interactions of various anti-diabetic drugs with NSAIDs.